COPASI 4.47 (Build 309)$$$New Features since COPASI 4.46 (Build 300)$$$Simulation Engine$$$Multi threading for population based optimization methods Differential Evolution; Evolutionary Programming; Evolution Strategy (SRES); Genetic Algorithm; Genetic Algorithm SR; Particle Swarm; and Scatter Search speeding up optimization and parameter estimation tasks.$$$Command Line (CopasiSE)$$$Added option to import and export task settings.$$$Bug Fixes and Enhancements since COPASI 4.46 (Build 300)$$$Graphical User Interface (CopasiUI)$$$Opening files from URL when clicking on a link on a website is again functional.$$$Tool Profile Likelihood: This tool now also works with just one parameter.$$$Tool Create Events from Time Series Experiment allows now the selection of the experiment if multiple experiments are specified.$$$Scan Sub Task Output: The tool tips for the check boxes have been corrected.$$$Parameter Estimation: Improved behavior when stopping the process to return complete plots.$$$Simulation Engine$$$Time Course RADAU5: Improved method to properly support multi threading.$$$Optimization Scatter Search: Fixed issue detecting improvements in solution.$$$Increased stack size under Windows to prevent randomly occurring access violations.

COPASI 4.45 (Build 298) Latest$$$@shoops shoops released this Apr 23$$$· 3 commits to develop since this release$$$ Build-298$$$ d1ad0fd$$$The COPASI team announces the immediate availability of the stable release COPASI 4.45 (Build 298).$$$A new release of COPASI has been made available. Please visit our free download page to retrieve this latest development release. Please note this version is released under the Artistic License 2.0; which is an OSI approved license. This license allows non-commercial and commercial use free of charge.$$$$$$New Features since COPASI 4.44 (Build 295)$$$Graphical User Interface (CopasiUI)$$$Added a new tool which attempts to convert ODEs into reactions.$$$Added a menu entry which allows definition and subsequent execution of user defined tools.$$$Standards$$$SBML Import added an option determining how to handle the import of initial values initial references.$$$Bug Fixes and Enhancements since COPASI 4.44 (Build 295)$$$Graphical User Interface (CopasiUI)$$$Optimization and Parameter Estimation: Whether to display the population dynamics is now part of the problem specification.$$$Fixed deletion of plots in the plot overview.$$$Fixed issue where event targets where not longer added to plots; reports; and time series.$$$Fixed crash occurring when switching the plot engine to: Qt DataVizualization (surface) for non surface plots.$$$Improved labels for surface plots which where limited to 2 decimal digits.$$$Fixed problem with notes of global quantities occurring when copying.$$$Time course Method Hybrid (RK-45): Selecting the partitioning strategy: user defined and selecting the deterministic reactions caused a crash.$$$Fixed delay during start on some Windows 11 installations caused while saving the known MIRIAM resources.$$$Functions: It is not longer permitted to copy mass action kinetics.$$$Fixed crash occurring when repeatedly deleting parameter sets.$$$Fixed problem deleting multiple global quantities.$$$Fixed crash when deleting interdependent global quantities.$$$Command Line (CopasiSE)$$$The argument to the option --report-file is now taken relative to the current working directory.$$$Steady-State: Added warning message indicating that no steady-state was found.$$$Simulation Engine$$$MCA: Fixed scaling for small compartment volumes.$$$Steady-State: Fixed occasionally occurring problem calculating the target criterions for models containing moieties; which lead to not finding a steady-state.$$$Events: Fixed crash caused by invalid trigger expression.$$$Time Course: Fixed output of all steps when the duration is negative.$$$Parameter Estimation: Non existing constraint objects will lead to a warning message.$$$Standards$$$SED-ML: Improved import of time course option initial time and number of points.$$$SBML: Improved import of reaction IDs used in multiple assignments.$$$SBML: Improved import of files containing reaction kinetics with missing parameters.

COPASI 4.45 (Build 298) Latest$$$@shoops shoops released this Apr 23$$$· 3 commits to develop since this release$$$ Build-298$$$ d1ad0fd$$$The COPASI team announces the immediate availability of the stable release COPASI 4.45 (Build 298).$$$A new release of COPASI has been made available. Please visit our free download page to retrieve this latest development release. Please note this version is released under the Artistic License 2.0; which is an OSI approved license. This license allows non-commercial and commercial use free of charge.$$$$$$New Features since COPASI 4.44 (Build 295)$$$Graphical User Interface (CopasiUI)$$$Added a new tool which attempts to convert ODEs into reactions.$$$Added a menu entry which allows definition and subsequent execution of user defined tools.$$$Standards$$$SBML Import added an option determining how to handle the import of initial values initial references.$$$Bug Fixes and Enhancements since COPASI 4.44 (Build 295)$$$Graphical User Interface (CopasiUI)$$$Optimization and Parameter Estimation: Whether to display the population dynamics is now part of the problem specification.$$$Fixed deletion of plots in the plot overview.$$$Fixed issue where event targets where not longer added to plots; reports; and time series.$$$Fixed crash occurring when switching the plot engine to: Qt DataVizualization (surface) for non surface plots.$$$Improved labels for surface plots which where limited to 2 decimal digits.$$$Fixed problem with notes of global quantities occurring when copying.$$$Time course Method Hybrid (RK-45): Selecting the partitioning strategy: user defined and selecting the deterministic reactions caused a crash.$$$Fixed delay during start on some Windows 11 installations caused while saving the known MIRIAM resources.$$$Functions: It is not longer permitted to copy mass action kinetics.$$$Fixed crash occurring when repeatedly deleting parameter sets.$$$Fixed problem deleting multiple global quantities.$$$Fixed crash when deleting interdependent global quantities.$$$Command Line (CopasiSE)$$$The argument to the option --report-file is now taken relative to the current working directory.$$$Steady-State: Added warning message indicating that no steady-state was found.$$$Simulation Engine$$$MCA: Fixed scaling for small compartment volumes.$$$Steady-State: Fixed occasionally occurring problem calculating the target criterions for models containing moieties; which lead to not finding a steady-state.$$$Events: Fixed crash caused by invalid trigger expression.$$$Time Course: Fixed output of all steps when the duration is negative.$$$Parameter Estimation: Non existing constraint objects will lead to a warning message.$$$Standards$$$SED-ML: Improved import of time course option initial time and number of points.$$$SBML: Improved import of reaction IDs used in multiple assignments.$$$SBML: Improved import of files containing reaction kinetics with missing parameters.