Prism 10.5.0$$$May 29; 2025$$$Whats New in Prism 10.5.0!$$$$$$Major improvements for Kaplan-Meier survival analysis:$$$New Number at Risk table automatically added to graphs of survival analysis**$$$Perform Multiple Pairwise Comparisons of groups following the log-rank test*$$$Obtain the 95% Confidence Interval for Median Survival for each group$$$Improved support for data sampled from lognormal distributions: analyze data without transformations and obtain results on the same scale as the input data$$$Lognormal t test and Lognormal Welchs t test$$$Lognormal one-sample t test$$$Lognormal ordinary and Brown-Forsythe/Welch one-way ANOVA$$$Get quicker insights from data exploration with multiple variables graphs: new controls allow you to quickly toggle through axis variable assignments for multiple variables graphs; visually investigating different relationships in your data*$$$Collaborate effortlessly with Prism Cloud: allow your colleagues to download your published projects from Prism Cloud; make changes; and publish their own updates back to the same Cloud project***$$$Improved file auto-recovery to increase Prisms ability to restore previously corrupted project files$$$Performance and stability improvements throughout the application

Statistical analysis and graphing software

Prism 10.4.2 was released on April 03; 2025.$$$$$$This release delivers multiple dependency patches; fixes; and upgrades to enhance the overall security; stability; and performance of the application.

Statistical analysis and graphing software

Prism 10.4.1$$$December 05; 2024$$$This release fixes multiple issues present in Prism versions 10.4.0 and older; including a fix for an issue that made it difficult or impossible to edit or modify embedded tables on graphs; and improves the behavior of logging in and out of a LabArchives account from the Prism desktop application.

Prism 10.4.0$$$October 29; 2024$$$Whats New in Prism 10.4.0!$$$$$$New nonlinear dose-response models: Gaddum-Schild competitive inhibition binding models for nonlinear regression$$$More intuitive controls for multiple variable heat maps: improved axis controls to customize heat maps generated from multiple variables data.$$$Dotmatics Luma integration: seamlessly connect your Prism projects and data with Dotmatics Luma - the scientific data management platform that seamlessly centralizes and optimizes your data lifecycle to handle both the volume and complexity of your scientific data in one place$$$Improved file auto-recovery to increase Prisms ability to restore previously corrupted project files$$$Performance and stability improvements throughout the application

Prism 10.3.1 was released on August 28; 2024.$$$$$$This release fixes multiple issues present in Prism versions 10.3.0; including a fix for an issue that could lead to a crash while performing unpaired t tests; and a fix for an issue that could cause some results of nonlinear regression to be incorrectly reported as blank$$$$$$Analysis Bug Fixes$$$Fixed an issue in which Prism would crash while performing an Unpaired t test from a grouped data table with error values and data that contained several data sets$$$Fixed an issue in which blank results were incorrectly displayed in the Outliers tab of the Nonlinear Regression analysis after adding empty data sets to the data table$$$Graphing Bug Fixes$$$(Mac) Fixed the issue in which the area fill of XY graphs appeared corrupted if some points were out of the Y-axis limits$$$(Mac) Fixed the issue in which unexpected data points appeared on Interleaved bar graphs for which symbols were enabled$$$Other Bug Fixes$$$Fixed the issue in which it was impossible to open flies with undefined parameters for disabled transforms$$$Fixed the hierarchical clustering link in the Dendrogram section of the Format Graph dialog$$$(Windows) Fixed the issue in which Prism would crash while performing the undo action to revert the magic operation for a graph with CLD labels and a non-default color scheme$$$(Windows) Fixed the issue in which Prism would crash while typing text over the existing text of floating notes$$$(Mac) Fixed the issue in which Prism would crash while switching to the Dendrogram tab of the Format Graph dialog if previously the Dendrogram data object was disabled for the default Dendrogram graph from Hierarchical Clustering and the graph type was changed to Heatmap using the Change Graph Type dialog$$$(Mac) Fixed the issue in which Prism would crash while changing the orientation of a dendrogram created for the hierarchical clustering sample data

Welcome to Prism 10.3.0!$$$More advanced statistical methods; machine-learning algorithms; sample size and power analysis; new stunning visualizations; modern authentication and license provisioning tools. This Prism release has it all; including:$$$$$$Sample size and power analysis*: quickly determine the number of samples or subjects that you need for your experimental design; explore the relationships between sample size and power; investigate the smallest detectable effect size when working with a limited number of samples or subjects.$$$Hierarchical clustering**: uncover the natural connections between observations in your data. This machine learning technique allows you to investigate how closely different observations are related to each other and uncover groupings within your data.$$$K-means clustering**: specify a target number of clusters; and this machine learning algorithm will partition your data; iteratively grouping the most similar observations together and adjusting cluster assignments.$$$Dendrograms**: visualize the hierarchical relationships from clustering analyses. Use dendrograms as an independent graph or as part of a heatmap from the output of hierarchical clustering.$$$Confidence ellipses and convex hulls**: visually represent estimates for the parameters that define the population from which your data were drawn; or clearly indicate the boundaries for groups of data on your graphs.$$$TeX-rendered equations for nonlinear regression: add high-quality; formatted equations from nonlinear regression onto your graphs. Insert formulas that include best-fit parameter values directly beside your graphed curves.$$$And much more!!

Prism 10.2.3 was released on April 30; 2024.$$$$$$This release fixes multiple issues present in Prism versions 10.2.0-10.2.2; including an issue in which a file corruption may occur if the system folder that Prism uses as its working directory is write-protected.$$$$$$The default working directory for Prism 10 depends on whether youre on Windows or macOS:$$$$$$Windows: %APPDATA%\GraphPad Software\Prism\10.0\Data$$$macOS: ~/Library/Application Support/GraphPad/Prism/10/run$$$Analysis Bug Fixes$$$(Mac) Fixed the issue in which it was impossible to select the option Compare row main effect on the Multiple Comparisons tab of the parameters dialog for Two-way ANOVA while using the Geisser-Greenhouse correction$$$Other Bug Fixes$$$Fixed the issue in which files may potentially become corrupted while using Prism if the system folder used for storing temporary Prism files is write protected$$$Fixed the issue in which an unexpected alert appeared when launching Prism offline if a rollback of the system time was detected while using a valid Prism license$$$(Mac) Implemented cryptographic routines associated with OpenSSL code within Prism to prevent the GoFetch attach on macOS devices with Apple Silicon$$$(Mac) Fixed the issue in which Prism was unable to save a project with corrupted images in the .pzfx format after saving it in the .prism format

Prism 10.2.2 was released on March 26; 2024.$$$$$$This release fixes multiple issues present in Prism version 10.2.0 and 10.2.1; including an update for a broken link to Prism Academy in the Welcome dialog; linear regression fixes; and improvements to data linking on graphs.$$$$$$Analysis Bug Fixes$$$Fixed the issue in which the results for Are the lines different? from Simple Linear Regression did not appear after converting a project from the .pzfx format to the .prism file format$$$Graphing Bug Fixes$$$Fixed an issue in which changing the levels of a categorical variable in a multiple variables data table did not correctly propagate to the graph$$$Other Bug Fixes$$$Fixed the links on the Videos tab of the Welcome dialog so that they correctly navigate to Prism Academy

Prism 10.2.1 was released on March 06; 2024.$$$$$$This version of Prism introduces a number of important fixes to issues present in previous versions of Prism. Notably; this version fixes a number of crashes related to issues present in the recalculation of nonlinear regression results as well as a number of other important fixes. See the complete release notes for more details.$$$$$$Graphing Bug Fixes$$$Fixed the issue in which graph formatting (colors; symbols; etc.) were not saved in projects with a huge number of graphs$$$Fixed the issue in which the labels of a Compact Letter Display appeared too far from the bars of Interleaved and Separated bar graphs$$$Fixed the issue in which Prism did not save the custom location of legends on a graph in a project containing a huge number of graph sheets$$$Fixed the issue in which confidence intervals were not displayed for data sets added to a graph using the Data Sets on Graph tab of the Format Graph dialog$$$(Mac) Fixed the issue in which the Equalize Scaling Factor dialog for layouts displayed the wrong scale values (%) for two graphs with different scales; resulting in unexpected behavior when trying to re-scale them automatically$$$Other Bug Fixes$$$Fixed the issue in which Prism would crash when performing Nonlinear regression with the EC50 shift; X is concentration model; and the option Does one curve adequately fit all the data sets selected if the data table only contained a single data set$$$Fixed the issue in which Prism would crash when duplicating data tables in a project with a huge number of data tables and results$$$Fixed the issue in which Prism would crash when opening a project file containing more than 500 sheets$$$(Win) Fixed the issue in which Prism would crash upon recalculating Principal Component Analysis or Cox Proportional Hazards Regression from graphs generated by these analyses$$$(Win) fixed the issue in which Prism was not able to open a file with analysis constants hooked to deleted/missing analyses$$$(Mac) Fixed the issue in which Prism would crash upon switching to the results of Nonlinear regression performed on a green results sheet if previously an entire data set was copy/pasted into the parent data table$$$(Mac) Fixed the issue in which subcolumn titles were arbitrarily adjusted to the left or right when copied from within Prism$$$(Mac) Fixed the issue in which Prism created an unneeded backup folder during the following actions:$$$Upon each invocation of the Change Graph Type dialog$$$Sswitching between graph types inside this dialog$$$Reordering graphs and layouts in the Navigator panel$$$Copying drawing or text objects

Prism 10.1.2 was released on December 14; 2023.$$$$$$This Windows-only release of Prism fixes an issue that began occurring after a recent Windows update and resulted in an error when trying to open embedded (OLE) Prism objects in Microsoft Office applications.$$$$$$WebView2 is a component developed and maintained by Microsoft; and allows desktop applications to incorporate different types of code and related functionalities. This component is installed on all modern Windows devices; and is used by all Prism versions starting with 9.3.0.$$$$$$After the Windows update on December 7; 2023 (WebView2 Build 120.0.2210.61); attempting to access embedded Prism files in Microsoft Office documents resulted in an error being displayed when trying to access these embedded files. One such error message (displayed when attempting to access embedded files from PowerPoint) is as follows:$$$$$$The server application; source file or item cant be found; or returned an unknown error. You may need to reinstall the server application$$$$$$Other alerts from other Microsoft Office applications (Word; Excel) may have somewhat different wording; but are all caused by the same issue that is fixed with this release.

Prism 10.1.0 was released on October 20; 2023.$$$$$$Prism 10.1.0 introduces a diverse set of new features and functionality along with a wide range of important bug fixes identified in previous versions of Prism 10.$$$$$$Feature Improvements$$$Introduced new options to define symbol size on Multiple Variables graphs. In addition to scaling symbol sizes by defining the smallest symbol size; you may now also choose to scale by defining the largest symbol size. OR you can define both the smallest and the largest symbol sizes; and Prism will appropriately scale all symbol sizes in between!$$$$$$Analysis Bug Fixes

Prism 10.0.0 was released on July 11; 2023.$$$$$$Prism 10: A Quick Glance$$$Powerful data analysis. Advanced graph customization. Simplified collaboration$$$Break down data silos: Introducing a more open file format that enables new workflows and integrations$$$Simplified interpretation of results: A new responsive “One or None” P value summary style$$$More comprehensive analysis: Default multiple comparison method for two-way ANOVA$$$Graph Inspector: A new interactive approach to multiple variable graph customization$$$Expanded data capabilities: Faster performance and support for larger data sets$$$Wrangle your data with new tools: New functions; new syntax; new outputs; and much more$$$Access more results: An all-new analysis constant dialog$$$Collaboration simplified: Publish; share; and discuss your work with Prism Cloud beta$$$And much; much more!

Prism 9.5.1 was released on February 08; 2023.$$$$$$Graphing Bug Fixes$$$(Mac) Fixed the issue in which column graphs created from the Create New Graph did not include error bars$$$Other Bug Fixes$$$Fixed the issue in which the floating note Paired tests require three or more pairs was not shown after performing a Wilcoxon t test analysis for data that did not contain any paired values$$$Fixed a typo in the results sheet of PCA